Orbach Lab

“The greatest obstacle to discovery is not ignorance -
it is the illusion of knowledge ”

Daniel J. Boorstin

Research

Our lab is fascinated by self-assembly and dynamic behavior of the microtubule cytoskeleton. We are especially interested in the ciliary cytoskeleton, known as the axoneme. Using cutting-edge microscopy techniques, advanced biochemistry, quantitative image analysis and various multidisciplinary approaches we aim to answer basic questions related to the cilia.

New Review: Microtubule Inner Proteins – Bridging Structure and Function in Ciliary Biology

We are thrilled to share the first publication from the Orbach Lab , a Journal of Cell Science Review titled “Microtubule Inner Proteins – Bridging Structure and Function in Ciliary Biology,” written together with Miao Gui . This Review highlights the remarkable progress in understanding how microtubule inner proteins (MIPs) organize the ciliary doublet microtubules from within—stabilizing the axoneme, shaping its periodic architecture, and fine-tuning ciliary motility. We

Welcome Rima to the Orbach Lab!

We are delighted to welcome Rima Sliman, who recently completed her B.Sc. in Biology and Medical Sciences at the University of Haifa. Rima brings with her a strong background in molecular biology, microbiology, and genetics, along with hands-on experience in DNA extraction, PCR, bacterial cultures, and microscopy. Beyond her scientific training, Rima has been deeply involved in academic mentoring and youth education, combining curiosity, dedication, and a genuine passion for

Faculty Retreat 2025 | Kfar Blum

The Orbach Lab took part in this year’s Faculty Retreat at the beautiful Kfar Blum! 🌿 All lab members joined the retreat, which was...

Highlighted Publication

Microtubule inner proteins – bridging structure and function in ciliary biology

Microtubule inner proteins (MIPs) have been brought into focus by the cryo-EM revolution. This Review outlines current knowledge, emerging functions, links to ciliopathies and outstanding questions in ciliary biology related to MIPs.